[Mesothelial proliferation of the tunica vaginalis testis]
K Greimelmaier1, J Wohlschläger2,3, A Probst4
1Institut für Pathologie, Diakonissenkrankenhaus Flensburg, Knuthstr. 1, 24939, Flensburg, Deutschland. greimelmaierkr@diako.de.
Abstract:
Proliferative changes seen in reactive mesothelial hyperplasia of a hydrocele sac may mimic malignant mesothelioma. There is no immunohistochemical staining that reliably separates benign from malignant mesothelial proliferations. However, the combined analysis of BAP1 by immunohistochemistry and CDKN2A by FISH has been reported to yield both a high specificity and sensitivity in this differential diagnosis. In addition, the evaluation of risk factors such as asbestos exposure or prior traumata may be helpful for the correct diagnosis. Exclusion of stromal invasion, which is diagnostic for malign mesothelioma, is of utmost importance. Therefore, extended histological workup is essential.
Related Concept Videos
Testes: Histology
The spermatogenic cells, responsible for producing sperm, are...
Testes: Gross Anatomy
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....


