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Related Experiment Videos

Tumor necrosis factor alpha: a multifaceted peptide hormone.

M G Rosenblum1, N J Donato

  • 1Department of Clinical Immunology and Biological Therapy, M.D. Anderson Hospital, Houston, Texas.

Critical Reviews in Immunology
|January 1, 1989
PubMed
Summary

Tumor necrosis factor-alpha (TNF-alpha) is a peptide hormone with broad biological effects, including immune modulation and growth regulation. Research explores its potential in treating neoplastic diseases, alone or with other agents.

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Area of Science:

  • Immunology
  • Cellular Biology
  • Oncology

Background:

  • Cellular homeostasis involves complex interactions between various signaling molecules.
  • Tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin (LT, TNF-beta) are homologous peptide hormones involved in host defense.
  • These factors also play roles in inflammatory, infectious, and neoplastic disease states.

Purpose of the Study:

  • To investigate the broad biological and immunologic effects of TNF-alpha.
  • To explore the growth-regulatory effects of TNF-alpha, both alone and in combination with other agents.
  • To assess the potential of TNF-alpha in treating neoplastic diseases.

Main Methods:

  • Review of existing literature on TNF-alpha and related cytokines.
  • Analysis of biological and immunologic effects, including antiviral, growth regulation, and immunomodulation.

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  • Examination of cooperative growth-regulatory effects with antitumor drugs and other bioactive peptides.
  • Consideration of ongoing clinical trials for neoplastic diseases.

    • Main Results:

    • TNF-alpha exhibits a wide range of biological effects, including antiviral, growth regulation, and immunomodulation.
    • It shares biological actions with other cytokines like IL-1, IFN-alpha, IFN-gamma, and TNF-beta.
    • TNF-alpha demonstrates both positive and negative cooperative growth-regulatory effects.
    • Clinical trials are evaluating its efficacy against various human cancers.

    Conclusions:

    • TNF-alpha is a significant peptide hormone with diverse biological functions relevant to disease.
    • Its growth-regulatory properties suggest potential therapeutic applications in oncology.
    • Further clinical investigation is warranted to determine its effectiveness in cancer treatment.