A Neonate with CLOVES Syndrome.

Area of Science:

• Genetics
• Dermatology
• Pediatrics

Background:

• Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) syndrome is a rare disorder.
• The CLOVE acronym was extended to CLOVES to include skeletal and central nervous system anomalies.
• This syndrome presents with a complex constellation of vascular, adipose, and epidermal abnormalities.

Purpose of the Study:

• To report an extremely rare case of CLOVES syndrome.
• To detail the specific clinical manifestations in this unique presentation.
• To contribute to the understanding of CLOVES syndrome variability.

Main Methods:

• Case report of a patient with CLOVES syndrome.
• Clinical examination and documentation of physical findings.
• Review of existing literature on CLOVES syndrome.

Main Results:

• The patient presented with lipomatous overgrowth in the cheek, facial asymmetry, hemangiomas, and large port-wine stains.
• Skeletal abnormalities included a widened first interdigital space, nail dystrophy, and bilateral hypertrophy of the first digits of the feet.
• This case expands the known spectrum of clinical findings in CLOVES syndrome.

Conclusions:

• CLOVES syndrome is a complex disorder with diverse clinical presentations.
• Early recognition and comprehensive management are crucial for patients with CLOVES syndrome.
• This case underscores the importance of detailed phenotyping in rare genetic disorders.