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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Related Experiment Video

Updated: Apr 20, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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Dermascope guided multiple reference optical coherence tomography.

Roshan Dsouza1, Hrebesh Subhash1, Kai Neuhaus1

  • 1Tissue Optics and Microcirculation Imaging Group, School of Physics, National University of Ireland, Galway, Ireland.

Biomedical Optics Express
|November 18, 2014
PubMed
Summary
This summary is machine-generated.

This study demonstrates a novel, low-cost optical coherence tomography (OCT) system integrated with a dermascope. This combined device offers simultaneous surface and subsurface imaging for accessible point-of-care dermatological diagnostics.

Keywords:
(100.2000) Digital image processing(100.3175) Interferometric imaging(110.4500) Optical coherence tomography(130.3120) Integrated optics devices(170.3880) Medical and biological imaging

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Dermatology

Background:

  • Point-of-care diagnostics are crucial in dermatology.
  • Existing imaging techniques may lack subsurface resolution.
  • Integrating multiple imaging modalities can enhance diagnostic capabilities.

Purpose of the Study:

  • To report the feasibility of a novel, low-cost optical coherence tomography (OCT) system integrated with a dermascope.
  • To develop a system for simultaneous superficial and subsurface imaging in dermatology.
  • To enable point-of-care dermatological applications.

Main Methods:

  • Development of an enhanced time-domain optical coherence tomography (OCT) system, termed multiple reference OCT (MR-OCT).
  • Utilized a miniature voice coil actuator and partial mirror to extend axial scan range.
  • Implemented interactive beam steering for simultaneous dermascope imaging and OCT subsurface data acquisition.
  • Enabled user-guided depth-resolved information retrieval via mouse cursor interaction.

Main Results:

  • Demonstrated the feasibility of integrating a low-cost OCT system with a dermascope.
  • Achieved simultaneous registration of superficial dermascope images and depth-resolved OCT subsurface information.
  • The interactive beam steering method allows for targeted subsurface analysis.

Conclusions:

  • The combined dermascopic OCT approach is a powerful optical imaging modality for dermatological applications.
  • Low-cost OCT integration with dermoscopy enhances diagnostic potential.
  • Hand-held devices can facilitate point-of-care and remote dermatological monitoring.