Optical coherence Doppler tomography for quantitative cerebral blood flow imaging
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Updated: Apr 20, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Jiang You1, Congwu Du1, Nora D Volkow2
1Department of Biomedical Engineering Stony Brook University, Stony Brook, NY 11794, USA.
Abstract:
Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold; in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular/arteriolar flows. ODT was able to identify cocaine-elicited microischemia and quantify CBFv disruption in branch vessels and capillaries that otherwise would have not been possible.
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