Related Experiment Videos
Maedi-visna in sheep: host-virus interactions and utilization as a model
G Pétursson1, P A Pálsson, G Georgsson
1Institute for Experimental Pathology, University of Iceland, Keldur, Reykjavík.
Intervirology
|January 1, 1989
Abstract:
Controlled animal experiments with the ovine maedi-visna virus, the prototype lentivirus, have been carried out for almost 40 years. This non-oncogenic virus leads to a life-long, persistent infection with slow development of lesions in the lungs and in the central nervous system. The virus is present in many cells in a DNA provirus state and its replication and expression is highly restricted in vivo. The basic biological features of maedi-visna virus are quite similar to those of HIV and this ovine lentiviral disease may be useful as a model for infection with human lentiviruses.