Related Experiment Video
Updated: Apr 20, 2026

Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay
Published on: May 1, 2019
A new diketopiperazine heterodimer from an endophytic fungus Aspergillus niger
Xiao-Bin Li1, Yue-Lan Li, Jin-Chuan Zhou
1a Department of Natural Products Chemistry , Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Science, Shandong University , Jinan 250012 , China.
Abstract:
One new diketopiperazine heterodimer, asperazine A (1), and eight known compounds, asperazine (2), cyclo(d-Phe-l-Trp) (3), cyclo(l-Trp-l-Trp) (4), 4-(hydroxymethyl)-5,6-dihydro-pyran-2-one (5), walterolactone A (6), and campyrones A-C (7-9), were isolated from an endophytic fungus Aspergillus niger. Their structures were determined unequivocally on the basis of extensive spectroscopic data analysis. This is the first report of the presence of compound 3 as a natural product. Cytotoxicity test against human cancer cell lines PC3, A2780, K562, MBA-MD-231, and NCI-H1688 revealed that compounds 1 and 2 had weak activities.
More Related Videos
12:02An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
11:44Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Related Concept Videos
Antifungal Agents
Basicity of Heterocyclic Aromatic Amines
Fungal Phylum Ascomycota
Structure of Amines
Production of Antibiotics
Aryldiazonium Salts to Azo Dyes: Diazo Coupling