Related Experiment Video

Updated: Apr 20, 2026

Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.8K

Influences of topical cyclopentolate on anterior chamber parameters with a dual-Scheimpflug analyzer in healthy

Emre Güler, Fatma Betül Güragaç, Aylin Tenlik

    Journal of Pediatric Ophthalmology and Strabismus
    |November 18, 2014
    PubMed

    Insights

    Topical cyclopentolate hydrochloride 1% significantly increased anterior chamber depth, volume, angle, and pupil size in children. Central corneal thickness remained unchanged. These findings impact biometric measurements and refractive surgery planning.

    Area of Science:

    • Ophthalmology
    • Optometry
    • Pediatric eye care

    Background:

    • Accurate anterior segment measurements are crucial for pediatric eye care.
    • Cyclopentolate hydrochloride is commonly used for cycloplegia.
    • The Galilei dual-Scheimpflug analyzer (GSA) provides detailed anterior segment imaging.

    Purpose of the Study:

    • To evaluate the effect of topical cyclopentolate hydrochloride 1% on anterior segment parameters in healthy children.
    • To assess the utility of the Galilei dual-Scheimpflug analyzer (GSA) for these measurements.

    Main Methods:

    • Fifty healthy children (mean age 10.27 years) received three drops of cyclopentolate hydrochloride 1%.
    • Anterior segment parameters (ACD, ACA, ACV, CCT, pupil size) were measured using the GSA before and 60 minutes after instillation.
    • Paired t-tests were used for statistical analysis.

    Main Results:

    • A statistically significant increase was observed in anterior chamber depth (ACD), anterior chamber angle (ACA), anterior chamber volume (ACV), and pupil size (P < .05).
    • Central corneal thickness (CCT) showed no significant change (P > .05).

    Conclusions:

    • Topical cyclopentolate hydrochloride 1% induces significant changes in multiple anterior segment parameters in children.
    • These induced changes must be considered when performing biometric measurements and planning refractive surgery in pediatric populations.
    • The GSA is effective in detecting these drug-induced changes.
    Abstract

    More Related Videos

    Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye09:03

    Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

    Published on: June 20, 2015

    10.6K

    Related Concept Videos

    Open Angle Glaucoma: Treatment01:27

    Open Angle Glaucoma: Treatment

    In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
    Drugs such as carbonic anhydrase inhibitors, α2- and...
    1.1K
    Angle Closure Glaucoma: Treatment01:28

    Angle Closure Glaucoma: Treatment

    Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
    1.7K
    Ophthalmic Drug Delivery Systems01:23

    Ophthalmic Drug Delivery Systems

    Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
    256
    Glaucoma: Overview01:25

    Glaucoma: Overview

    Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
    1.7K