Experimental study of the efficiency of oxidized dextran for prevention of influenza A/H5N1
V A Shkurupy1, O V Potapova, T V Sharkova
1Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Bulletin of Experimental Biology and Medicine
|November 19, 2014
Abstract:
Oxidized dextran is suggested for prevention of infection induced by influenza A/H5N1 viruses, methods of its use and doses are determined. Two intravenous injections of dextran 3 and 1 days before experimental infection of outbred mice by influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus resulted in a high preventive dose-dependent effect: the mean lifespan was 25% prolonged, the mortality decreased 3-fold.
