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Does ocriplasmin affect the RPE-photoreceptor adhesion in macular holes?
A Hager1, I Seibel1, A Riechardt1
1Department of Ophthalmology, Charite -Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
The British Journal of Ophthalmology
|November 19, 2014
Summary
Vitrectomy resolved vitreomacular traction (VMT) and macular holes after ocriplasmin treatment failed. Some patients developed persistent subretinal fluid post-vitrectomy, possibly due to ocriplasmin
Area of Science:
- Ophthalmology
- Retinal Surgery
- Pharmacological Treatments
Background:
- Evaluating anatomical outcomes after vitrectomy for persistent symptomatic vitreomacular traction (VMT).
- Focus on cases with full-thickness macular holes (FTMHs) under 400 µm after ocriplasmin treatment.
Purpose of the Study:
- Assess the anatomical results of vitrectomy in patients with persistent VMT and FTMHs.
- Investigate outcomes following unsuccessful ocriplasmin treatment.
Main Methods:
- Retrospective, single-center study of consecutive patients.
- Single intravitreal injection of ocriplasmin administered.
- Pars-plana vitrectomy (PPV) performed for persistent VMT and FTMHs.
Main Results:
- Ocriplasmin injection failed to resolve VMT in most patients (4/5).
- Four patients underwent PPV for persistent VMT and FTMHs.
- FTMHs closed within a week post-PPV; however, 3 patients developed new, persistent subretinal fluid.
Conclusions:
- Vitrectomy can resolve VMT and close FTMHs after failed ocriplasmin treatment.
- Newly developed subretinal fluid post-vitrectomy, potentially linked to ocriplasmin's enzymatic activity, was observed.
- Long-term effects of ocriplasmin require further evaluation with spectral-domain optical coherence tomography (SD-OCT).
