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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Related Experiment Video

Updated: Apr 20, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Comparative Lesions Analysis Through a Targeted Sequencing Approach

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Deciphering tumor growth by clonal analysis.

Gregory Driessens1

  • 1Université Libre de Bruxelles, IRIBHM.

Critical Reviews in Oncogenesis
|November 19, 2014
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive tumor growth and relapse. Recent lineage tracing methods confirm their hierarchical role in unperturbed tumors, offering new therapeutic targets.

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Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

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Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Tumor growth mechanisms are a key focus in cancer research.
  • The cancer stem cell (CSC) model hypothesizes a hierarchical tumor organization.
  • CSCs are implicated in tumor growth, treatment resistance, and relapse.

Purpose of the Study:

  • To review the role of cancer stem cells (CSCs) in tumor hierarchy.
  • To discuss the utility of lineage tracing methods in studying CSCs.
  • To explore therapeutic strategies targeting CSCs.

Main Methods:

  • Review of recent literature on cancer stem cells and tumor hierarchy.
  • Focus on clonal analysis and lineage tracing tools.
  • Discussion of experimental models for CSC characterization.

Main Results:

  • Evidence supports the CSC model, demonstrating hierarchical organization in vivo.
  • Lineage tracing confirms CSCs' role in unperturbed tumor growth.
  • Intratumoral heterogeneity is functionally significant.

Conclusions:

  • Lineage tracing provides unique opportunities to characterize CSCs.
  • Understanding CSCs is crucial for developing targeted therapies.
  • CSCs are key targets for overcoming cancer relapse and treatment resistance.