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Updated: Apr 20, 2026

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
Published on: March 8, 2018
Rubeosis iridis in patients with diabetes: not forgetting oculoischaemic syndrome as a differential
Magdalena Niestrata-Ortiz1, Ji-Peng Olivia Li2, Nigel Davies1
1Chelsea and Westminster Hospital, London, UK.
Abstract:
This case illustrates an oculoischaemic syndrome presenting with iris neovascularisation in a patient with established diabetic retinopathy. It highlights the importance of considering the differential diagnosis of rubeosis in all patients, including those with an underlying vascular pathology. Moreover, it urges clinicians to consider the sequelae of a compromised vascular system, such as the iatrogenic central retinal artery occlusion as a result of intravitreal injections. Early diagnosis not only informs correct ophthalmic treatment, but is crucial in preventing ischaemic stroke and, therefore, reducing the risk of systemic morbidity and mortality.
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