Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Selectins01:25

Selectins

4.9K
Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
4.9K
Structure and Function of Platelets01:18

Structure and Function of Platelets

7.1K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
7.1K
Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

5.7K
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
5.7K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

11.1K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
11.1K
Proteoglycans01:05

Proteoglycans

5.3K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
5.3K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.9K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the role of sialidases in Galectin-1-associated resistance to cancer therapies.

Biochimica et biophysica acta. General subjects·2026
Same author

Glycan-Binding Proteins in Immunity.

Annual review of immunology·2026
Same author

Platelet Releasate Reprograms Synovial Macrophages In Vitro: A New Approach in the Treatment of Hemophilic Synovitis.

International journal of molecular sciences·2025
Same author

Yellow fever virus infection triggers proinflammatory and prothrombotic responses in endothelial cells through NF-κB and MAPK signaling pathways.

Thrombosis research·2025
Same author

Shaping hematopoietic cell ecosystems through galectin-glycan interactions.

Seminars in immunology·2024
Same author

A C-type lectin from Bothrops jararacussu venom reprograms endothelial cell biology.

Angiogenesis·2024
Same journal

Towards haplotypes of blood group genes: the impact of long-read sequencing in molecular immunohematology.

Annals of translational medicine·2026
Same journal

Development of pharmacological interventions for the treatment of sarcopenia.

Annals of translational medicine·2026
Same journal

Fertility preservation in young women with breast cancer: a narrative review of effectiveness, oncologic safety, and clinical practice implications.

Annals of translational medicine·2026
Same journal

Propofol-based total intravenous anesthesia and recurrence-free survival after hepatectomy-does it improve outcomes?

Annals of translational medicine·2026
Same journal

Is pulmonary hypertension still a contraindication for lung volume reduction?-a narrative review of contemporary evidence.

Annals of translational medicine·2026
Same journal

Calcium montmorillonite clay: a clinically oriented narrative review of emerging perioperative and supportive applications.

Annals of translational medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

960

Platelets and galectins.

Mirta Schattner1

  • 1Laboratory of Experimental Thrombosis, Institute of Experimental Medicine-CONICET, National Academy of Medicine, Buenos Aires, Argentina.

Annals of Translational Medicine
|November 19, 2014
PubMed
Summary
This summary is machine-generated.

Platelets maintain vascular integrity and form clots. Recent research reveals galectins, a class of glycan-binding proteins, activate platelets through novel pathways, impacting hemostasis, thrombosis, and inflammation.

Keywords:
Galectinsplateletsthrombosis

More Related Videos

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

18.8K
Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System
11:04

Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System

Published on: October 16, 2013

12.7K

Related Experiment Videos

Last Updated: Apr 20, 2026

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
05:43

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

Published on: November 8, 2024

960
Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

18.8K
Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System
11:04

Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System

Published on: October 16, 2013

12.7K

Area of Science:

  • Hematology
  • Immunology
  • Molecular Biology

Background:

  • Platelets are crucial for hemostasis, forming plugs at vascular injury sites.
  • Dysfunctional platelet activation contributes to thrombosis, atherosclerosis, inflammation, and cancer.
  • Platelets respond to canonical agonists like thrombin, ADP, and collagen.

Purpose of the Study:

  • To explore recent advancements in platelet activation by non-canonical agonists.
  • To investigate the role of galectins in platelet activation pathways.
  • To hypothesize the broader implications of platelet-galectin interactions in health and disease.

Main Methods:

  • Review of recent scientific literature on platelet activation.
  • Analysis of signaling pathways modulated by galectins.
  • Formulation of new hypotheses regarding galectin functions.

Main Results:

  • Galectins, acting as soluble or immobilized agents, activate platelets.
  • These glycan-binding proteins trigger platelet responses via specific signaling cascades.
  • Platelet activation by galectins involves modulation of discrete signaling pathways.

Conclusions:

  • Galectins represent a novel class of non-canonical platelet agonists.
  • Platelet-galectin interactions are implicated in hemostasis, thrombosis, and inflammatory diseases.
  • Further research into galectins may uncover new therapeutic targets for cardiovascular and oncologic conditions.