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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Related Experiment Video

Updated: Apr 20, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Galectins in tumor angiogenesis.

Arjan W Griffioen1, Victor L Thijssen1

  • 11 Department of Medical Oncology, 2 Department of Radiation Oncology, Angiogenesis Laboratory, VU University Medical Center, Amsterdam, The Netherlands.

Annals of Translational Medicine
|November 19, 2014
PubMed
Summary
This summary is machine-generated.

Galectins are key regulators of tumor angiogenesis, the process of new blood vessel growth in solid tumors. Understanding galectin roles in endothelial cells (EC) offers potential cancer therapy targets.

Keywords:
Endotheliumcancerendothelial cell (EC)galectinglycosylationsproutingtargetingtherapy

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Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Solid tumor expansion relies on tumor angiogenesis, the formation of new blood vessels.
  • Tumor angiogenesis is a hallmark of cancer and a therapeutic target.
  • Endothelial cells (EC) are the primary mediators of tumor angiogenesis.

Purpose of the Study:

  • To review the current understanding of galectin involvement in tumor angiogenesis.
  • To focus on the specific roles of endothelial galectins (gal-1, -3, -8, -9) in this process.

Main Methods:

  • Literature review of scientific publications on galectins and tumor angiogenesis.
  • Analysis of the functional roles of specific galectins in endothelial cells.

Main Results:

  • Galectins have emerged as significant regulators of tumor angiogenesis in the past decade.
  • Specific galectins (gal-1, -3, -8, -9) play crucial roles within endothelial cells during neovascularization.

Conclusions:

  • Galectins are important molecular players in tumor angiogenesis.
  • Targeting endothelial galectins presents a promising avenue for anti-cancer therapies aimed at inhibiting tumor growth.