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Promethazine-montmorillonite inclusion complex to enhance drug photostability

Valeria Ambrogi1, Morena Nocchetti, Loredana Latterini

  • 1Dipartimento di Scienze Farmaceutiche and ‡Dipartimento di Chimica, Biologia e Biotecnologie, Università degli Studi di Perugia , 06123 Perugia, Italy.

Langmuir : the ACS Journal of Surfaces and Colloids
|November 20, 2014
PubMed

Insights

Montmorillonite (MONT) effectively enhances the photostability of photolabile drugs like promethazine (PRO). Intercalating PRO into MONT significantly slows its degradation, offering improved drug photoprotection.

Area of Science:

  • Materials Science
  • Pharmaceutical Science
  • Photochemistry

Background:

  • Photolabile drugs are susceptible to degradation upon light exposure, limiting their therapeutic applications.
  • Montmorillonite (MONT) has emerged as a promising matrix for enhancing drug photostability.
  • Understanding drug-matrix interactions is crucial for developing stable pharmaceutical formulations.

Purpose of the Study:

  • To investigate the photoprotective effects of montmorillonite (MONT) on promethazine (PRO), a model photolabile drug.
  • To characterize the intercalated hybrid material (MONT-PRO) and evaluate its photostability.
  • To assess the potential of MONT-PRO for pharmaceutical formulation.

Main Methods:

  • Drug intercalation of promethazine (PRO) into montmorillonite (MONT).
  • Characterization using X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and FTIR spectroscopy.
  • Photostability evaluation through spectrophotometric measurements and nanosecond transient absorption spectroscopy.

Main Results:

  • Successful preparation of MONT-PRO hybrid material with high drug loading.
  • Markedly improved photostability of PRO intercalated in MONT, with a 5-fold slower degradation rate compared to homogeneous solutions.
  • Suppression of drug photoionization and reduced singlet oxygen production due to matrix interaction.

Conclusions:

  • Montmorillonite (MONT) significantly enhances the photostability of promethazine (PRO).
  • The MONT-PRO intercalation compound demonstrates improved photoprotection, making it suitable for pharmaceutical applications.
  • MONT-PRO can be formulated into gels or ointments without compromising photostability.

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