Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.7K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.7K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

4.1K
4.1K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

6.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Graphene interconnects fully encapsulated in layered insulator hexagonal boron nitride.

Nanotechnology·2013
Same author

Methylation of a novel CpG island of intron 1 is associated with steroidogenic factor 1 expression in endometriotic stromal cells.

Reproductive sciences (Thousand Oaks, Calif.)·2013
Same author

Rare occurrence of the JAK1 mutation in acute promyelocytic leukemia patients.

Acta haematologica·2013
Same author

A systematic review and meta-analysis of buyang huanwu decoction in animal model of focal cerebral ischemia.

Evidence-based complementary and alternative medicine : eCAM·2013
Same author

Lower citrinin production by gene disruption of ctnB involved in citrinin biosynthesis in Monascus aurantiacus Li AS3.4384.

Journal of agricultural and food chemistry·2013
Same author

Semiconductor nanocrystals in sol-gel derived matrices.

Physical chemistry chemical physics : PCCP·2013
Same journal

Generation of human chemically induced pluripotent stem cells from UC-MSCs.

Cell regeneration (London, England)·2026
Same journal

Standard: human breast cancer organoids derived from diverse clinical sample sources.

Cell regeneration (London, England)·2026
Same journal

Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances.

Cell regeneration (London, England)·2026
Same journal

Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery.

Cell regeneration (London, England)·2026
Same journal

Advances in the application of human amniotic membrane for tissue repair.

Cell regeneration (London, England)·2026
Same journal

Cellular senescence in skeletal muscle regeneration.

Cell regeneration (London, England)·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

10.8K

Progress and bottleneck in induced pluripotency.

Zhen-Ning Zhang1, Yang Xu1

  • 1Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla California 92093-0322 USA.

Cell Regeneration (London, England)
|November 20, 2014
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) offer great potential for regenerative medicine and disease modeling. However, addressing genetic abnormalities and tumor risks is crucial for safe clinical applications.

More Related Videos

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

9.9K
A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.9K

Related Experiment Videos

Last Updated: Apr 20, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

10.8K
Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

9.9K
A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

6.9K

Area of Science:

  • Biotechnology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Induced pluripotent stem cells (iPSCs) are derived from somatic cells and can differentiate into any cell type, offering potential for cell therapy and disease modeling.
  • Advances in iPSC technology include improved safety and reprogramming efficiency, utilizing non-integrating methods and small molecules to avoid genetic modification and cancer risks.

Purpose of the Study:

  • To review the progress and challenges in iPSC technology, focusing on safety and clinical translation.
  • To highlight safety concerns including genetic/epigenetic abnormalities, immunogenicity, and oncogenic potential that need resolution for therapeutic use.

Main Methods:

  • Review of recent studies on iPSC generation, safety modifications, and therapeutic applications.
  • Analysis of genetic and epigenetic abnormalities, immunogenicity, and tumor suppressor pathway activation in iPSCs.

Main Results:

  • Non-integrating reprogramming methods and small molecule enhancers have improved iPSC generation efficiency and safety.
  • Identified safety concerns include genetic/epigenetic abnormalities, immunogenicity of derived cells, and activation of tumor suppressor pathways (e.g., p53, ARF).

Conclusions:

  • Despite significant progress, critical safety concerns related to genomic integrity and oncogenic potential must be addressed for the clinical development of iPSCs.
  • Resolving these safety issues is essential to fully realize the therapeutic potential of iPSCs in human cell therapy.