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Updated: Apr 20, 2026
Procedure for Fabricating Biofunctional Nanofibers
Published on: September 10, 2012
Ordered, adherent layers of nanofibers enabled by supramolecular interactions
Christopher B Highley1, Christopher B Rodell1, Iris L Kim1
1Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33 Street, Philadelphia, PA 19104, USA.
Abstract:
Aligned nanofibrous substrates can be created by electrospinning, but methods for creating multilamellar structures of aligned fibers are limited. Here, apposed nanofibrous scaffolds with pendant β-cyclodextrin (CD) were adhered together by adamantane (Ad) modified hyaluronic acid, exploiting the guest-host interactions of CD and Ad for macroscopic assembly. Stable user-defined multi-layered scaffolds were formed for cell culture or tissue engineering.
