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Related Experiment Videos

Normalised radionuclide measures of left ventricular diastolic function.

K J Lee1, A E Southee, G J Bautovich

  • 1Department of Nuclear Medicine, Royal Prince Alfred Hospital, Sydney, Australia.

European Journal of Nuclear Medicine
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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A simple radionuclide test can assess diastolic heart function. Normalizing peak filling rate to peak ejection rate provides a heart rate-independent measure for tracking diastolic dysfunction in patients with normal systolic function.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Physiology

Background:

  • Diastolic dysfunction is increasingly recognized in heart failure patients with preserved systolic function.
  • A simple, routine radionuclide measure for diastolic function is needed.
  • Current assessment methods may not be easily applicable in routine clinical settings.

Purpose of the Study:

  • To establish a simple radionuclide measure for left ventricular diastolic function.
  • To investigate the relationship between peak diastolic filling rate and heart rate, age, and ejection fraction.
  • To determine normal ranges for diastolic function parameters using regression analysis.

Main Methods:

  • Gated heart pool studies were performed on 64 subjects with normal cardiovascular systems.

Related Experiment Videos

  • Peak diastolic filling rate was normalized to end-diastolic volume, stroke volume, and peak systolic emptying rate.
  • Multiple regression analysis was used to determine relationships and establish normal ranges.

    • Main Results:

    • Peak filling rate normalized to end-diastolic volume correlated significantly with heart rate, age, and ejection fraction.
    • Normalization to stroke volume showed significant correlation with heart rate and age, but not ejection fraction.
    • Normalization to peak systolic emptying rate correlated only with age, indicating a heart rate-independent parameter.

    Conclusions:

    • Peak filling rate normalized to peak ejection rate is a heart rate-independent parameter useful for comparing diastolic and systolic function.
    • This measure can be used to serially monitor diastolic function in patients with normal systolic function.
    • Age-corrected normalization may aid in screening for diastolic dysfunction.