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Updated: Apr 20, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
State-of-the-art endovascular treatment of acute ischemic stroke
Guy Raphaeli1, Mikael Mazighi, Vitor Mendes Pereira
1Interventional Neuroradiology Unit, Rabin Medical Center, Beilinson Hospital, Petach-Tikva, Israel, graphaeli@gmail.com.
Insights
Mechanical neurothrombectomy offers faster recanalization for acute ischemic stroke (AIS) than current treatments. This review covers advanced devices and techniques for endovascular AIS therapy, including ongoing clinical trials.
Area of Science:
- Neurology
- Neurosurgery
- Interventional Radiology
Background:
- Stroke is a leading cause of death, with most cases being ischemic.
- Current treatments like intravenous thrombolysis have a narrow therapeutic window.
- Mechanical neurothrombectomy presents advantages for acute ischemic stroke (AIS) intervention.
Purpose of the Study:
- To review state-of-the-art neurothrombectomy devices and stenting techniques for AIS.
- To highlight recent advances in endovascular reperfusion therapies.
- To discuss ongoing clinical trials in the field.
Main Methods:
- Review of current literature on neurothrombectomy devices.
- Description of endovascular stenting techniques for AIS.
- Inclusion of data from ongoing clinical trials.
Main Results:
- Mechanical neurothrombectomy shows promise for rapid recanalization in AIS.
- Devices are effective for large-vessel occlusions, potentially reducing hemorrhagic risks.
- Advances in reperfusion therapies are expanding treatment options.
Conclusions:
- Mechanical neurothrombectomy is a rapidly evolving field for AIS treatment.
- Endovascular approaches offer significant advantages over traditional thrombolysis.
- Ongoing trials are crucial for further validating and advancing these therapies.
Abstract:
Stroke is the third leading cause of death in the USA. An estimated 795,000 new or recurrent stroke events occur annually, mostly ischemic in nature. Arterial recanalization and subsequent reperfusion performed shortly after symptom onset can help to restore brain function in acute ischemic stroke (AIS). The only treatment currently approved by the United States Food and Drug Administration is intravenous tissue plasminogen activator, administered within 4.5 h of symptom onset. However, this short window often precludes effective intervention. Mechanical neurothrombectomy devices offer many potential advantages over pharmacologic thrombolysis, including more rapid achievement of recanalization, enhanced efficacy in treating large-vessel occlusions, and a potentially lower risk of hemorrhagic events. The goal of this chapter is to describe the state-of-the-art neurothrombectomy devices and stenting techniques for endovascular treatment of acute ischemic stroke, as well as to highlight recent advances in reperfusion therapies. Ongoing clinical trials, some with randomized, controlled designs, are included.
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