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Published on: February 17, 2023
Optic pathway gliomas
Ben Shofty1, Liat Ben-Sira, Anat Kesler
1Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Medical Center, Tel Aviv University, 6th Weizmann St., Tel-Aviv, 64239, Israel.
Abstract:
Optic pathway gliomas (OPGs) are among the most challenging neoplasms in modern pediatric neuro-oncology. Recent technological advances in imaging, surgery, and chemotherapy may lead to better understanding of the pathophysiology and better clinical results. This chapter reviews these advances and the current treatment paradigms.
Insights
Optic pathway gliomas (OPGs) are challenging pediatric brain tumors. Advances in imaging, surgery, and chemotherapy offer improved understanding and treatment outcomes for these challenging neoplasms.
Area of Science:
- Pediatric Neuro-Oncology
- Neoplasm Pathophysiology
- Neuro-oncology Research
Background:
- Optic pathway gliomas (OPGs) represent complex pediatric neoplasms.
- Current understanding of OPG pathophysiology requires advancement.
- Treatment outcomes for OPGs necessitate improvement.
Purpose of the Study:
- To review recent technological advancements in OPG management.
- To discuss the impact of new technologies on OPG pathophysiology understanding.
- To outline current and emerging treatment paradigms for pediatric OPGs.
Main Methods:
- Literature review of recent technological innovations.
- Analysis of imaging, surgical, and chemotherapeutic advancements.
- Synthesis of current treatment strategies for OPGs.
Main Results:
- Technological progress in imaging enhances OPG detection and characterization.
- Surgical techniques are evolving for improved OPG resection.
- Chemotherapeutic regimens show promise for better clinical results in OPG treatment.
Conclusions:
- Recent advancements significantly improve the understanding and management of pediatric optic pathway gliomas.
- Integrated approaches utilizing novel imaging, surgical, and chemotherapeutic strategies are key.
- Future research directions focus on refining treatment paradigms for better pediatric neuro-oncology outcomes.
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