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Updated: Apr 20, 2026

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
Published on: April 1, 2013
Synthesis and characterization of fluorinated derivatives of cresolsulfonphthalein
Alexander V Kachur1, Diana Sardelis2, Catherine Bentzley2
1Department of Radiology, School of Medicine University of Pennsylvania, Philadelphia., PA 19104 ; Department of Chemistry and Biochemistry, Misher College of Arts and Sciences, University of the Sciences, Philadelphia, PA 19104.
Abstract:
The reaction between dilute fluorine gas and cresolsufonphthalein in acetic acid was investigated. The mono-, di-, and trifluorinated cresolsufonphthalein derivatives were isolated and characterized. These compounds possessed the properties of pH indicators with biologically relevant pKa values (6.4-7.5) and the absorption maxima of the basic forms at 582-592 nm. This method can be used for synthesis of positron-emitting 18F-labeled pH indicators with potential application for non-invasive in vivo pH measurement in biological objects.
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