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Related Concept Videos

Drug Therapy01:28

Drug Therapy

424
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
424
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

320
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
320
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

327
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
327
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

470
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
470
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

576
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
576
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

2.6K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
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Related Experiment Video

Updated: Apr 20, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

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Interventions for enhancing medication adherence.

Robby Nieuwlaat1, Nancy Wilczynski, Tamara Navarro

  • 1Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton General Hospital campus, Room C3-107, 237 Barton Street East, Hamilton, ON, Canada, L8L 2X2.

The Cochrane Database of Systematic Reviews
|November 21, 2014
PubMed
Summary
This summary is machine-generated.

Many patients do not take their medications as prescribed. Interventions to improve medication adherence and clinical outcomes show inconsistent results, indicating a need for more effective strategies.

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Last Updated: Apr 20, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Area of Science:

  • Pharmacology and Therapeutics
  • Evidence-Based Medicine
  • Health Services Research

Background:

  • Self-administered medications are often taken at half the prescribed dose.
  • Improving patient adherence to medication can enhance treatment efficacy.

Purpose of the Study:

  • To evaluate the impact of interventions designed to improve patient adherence to prescribed medications.
  • To assess effects on both medication adherence and clinical outcomes for various medical conditions.

Main Methods:

  • Systematic review and qualitative analysis of 182 randomized controlled trials (RCTs) up to January 2013.
  • Focus on RCTs with low risk of bias and at least six months follow-up for positive findings.
  • Data extraction by independent reviewers, with a third author resolving disagreements.

Main Results:

  • Included 182 RCTs, with 17 identified as having the lowest risk of bias.
  • Low-bias RCTs often used complex, multi-component interventions with tailored support from health professionals.
  • Only five low-bias RCTs demonstrated improvements in both adherence and clinical outcomes; effects were generally modest.

Conclusions:

  • Current interventions for medication adherence in chronic conditions are complex and not highly effective.
  • Significant advances are needed in intervention design, adherence measurement, and study power.
  • The study's database is available to facilitate collaborative research and advance the field.