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Dissecting the human protein-protein interaction network via phylogenetic decomposition

Cho-Yi Chen1, Andy Ho2, Hsin-Yuan Huang3

  • 1Genome and Systems Biology Degree Program, Department of Life Science, Institute of Molecular and Cellular Biology.

Scientific Reports
|November 22, 2014
PubMed
Summary

Ancient proteins form the core of the human protein-protein interaction (PPI) network, while younger proteins are peripheral. This age-based organization reflects evolutionary roles and subcellular localization in cells.

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