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Psoriasis is a systemic disease with multiple cardiovascular and metabolic comorbidities

Caitriona Ryan1, Brian Kirby2

  • 1Department of Dermatology, Baylor University Medical Center Dallas, 3900 Junius Street, Suite 145, Dallas, TX 75246, USA.

Dermatologic Clinics
|November 22, 2014
PubMed

Insights

Patients with moderate to severe psoriasis face higher risks of cardiovascular disease, obesity, and diabetes. Managing psoriasis inflammation may reduce these risks, though more research is needed.

Area of Science:

  • Dermatology
  • Cardiology
  • Endocrinology

Background:

  • Psoriasis is linked to increased risks of cardiovascular disease, obesity, diabetes mellitus, and metabolic syndrome.
  • Inflammatory pathways are implicated in the comorbidities associated with psoriasis.
  • Current understanding of the precise mechanisms linking psoriasis and cardiovascular disease requires further definition.

Purpose of the Study:

  • To review current literature on cardiovascular and metabolic comorbidities in psoriasis.
  • To identify existing research gaps in this field.
  • To propose management strategies for reducing cardiovascular risk in psoriasis patients.

Main Methods:

  • Literature review of studies on psoriasis and its associated cardiovascular and metabolic conditions.
  • Analysis of inflammatory pathways common to psoriasis and cardiovascular disease.
  • Synthesis of current evidence to inform management strategies.

Main Results:

  • Patients with moderate to severe psoriasis exhibit elevated risks for cardiovascular disease, obesity, diabetes, and metabolic syndrome.
  • Inflammatory processes are likely key mediators in the development of these comorbidities.
  • Robust evidence supporting the reduction of cardiovascular inflammation via systemic psoriasis treatment is still limited.

Conclusions:

  • Psoriasis is associated with significant cardiovascular and metabolic comorbidities.
  • Further research is necessary to elucidate the underlying mechanisms and confirm the benefits of anti-inflammatory treatments on cardiovascular health.
  • Proactive management of cardiovascular risk factors is crucial for patients with moderate to severe psoriasis.

Keywords:
CardiovascularComorbiditiesDiabetesMetabolic syndromeMyocardial infarctionObesityPsoriasisSmoking

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