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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Psoriasis: the future.

M Alan Menter1, Christopher E M Griffiths2

  • 1Division of Dermatology, Baylor University Medical Center at Dallas, Dallas, TX, USA.

Dermatologic Clinics
|November 22, 2014
PubMed
Summary
This summary is machine-generated.

Psoriasis encompasses diverse types, requiring tailored therapies. Future treatments will integrate clinical, pharmacogenomic, and immunologic data for personalized psoriasis management.

Keywords:
BiosimilarsDrug safetyPersonalized medicinePhenotypical variantsPsoriatic arthritisSystemic disease

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Area of Science:

  • Dermatology and immunology
  • Genetics and precision medicine

Background:

  • Psoriasis is a complex skin disease with diverse clinical presentations.
  • Understanding distinct psoriasis phenotypes and endotypes is crucial for effective treatment.

Purpose of the Study:

  • To highlight the evolving understanding of psoriasis heterogeneity.
  • To emphasize the future role of stratified medicine in psoriasis management.
  • To underscore the importance of comorbidities and their impact on psoriasis care.

Main Methods:

  • Review of current understanding of psoriasis phenotypes and endotypes.
  • Discussion of integrating clinical, pharmacogenomic, and immunologic data.
  • Analysis of associated comorbidities and their clinical implications.

Main Results:

  • Psoriasis is not a single disease but a spectrum of distinct subtypes.
  • Personalized medicine approaches integrating multiple data types are emerging.
  • Comorbidities significantly influence psoriasis management and research.

Conclusions:

  • Tailored therapies based on psoriasis endotypes will become standard.
  • A holistic approach considering comorbidities is essential for managing complex psoriasis cases.
  • Future research will focus on disease interdependence and personalized treatment strategies.