Related Experiment Video
Updated: Apr 20, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Co-Morbidity Part 2 - Neurobiology and Suicide Risk; Modelling the consequences of Bipolar and Anxiety Co-Morbidity
Mark Agius1, Norma Verdolini, Francesca Falzon Aquilina
1SEPT at Weller Wing, Bedford Hospital, Bedford, Bedfordshire, MK42 9DJ, UK, ma393@cam.ac.uk.
Abstract:
We review the evidence that Bipolar Disorder with Comorbid Anxiety, Rapid Cycling Bipolar Disorder, Mixed Affective states, are all related to each other and to Dopamine Transmission in Bipolar Disorder. All these states are related to the presence of particular polymorphisms of the genes of the D2 and D3 receptors. All these states increase the risk of suicidality. Substance and alcohol abuse comorbid with bipolar disorder increases the risk of both Rapid Cycling and Suicidality. We present a model which demonstrates these relationships.
Related Concept Videos
Bipolar Disorder
Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Bulimia Nervosa
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Social Anxiety Disorder

