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Updated: Apr 20, 2026

Defining Substrate Specificities for Lipase and Phospholipase Candidates
Published on: November 23, 2016
Glycerophosphate/Acylglycerophosphate acyltransferases
Atsushi Yamashita1, Yasuhiro Hayashi2, Naoki Matsumoto3
1Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. ayamashi@pharm.teikyo-u.ac.jp.
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) enzymes are crucial for synthesizing lipids. Their roles in metabolism, obesity, and phospholipid remodeling are explored.
Area of Science:
- Biochemistry
- Molecular Biology
- Metabolic Research
Background:
- Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are key enzymes in glycerolipid synthesis.
- Recent identification of GPAT/AGPAT family members has spurred research into their functions.
Purpose of the Study:
- To review the enzymology of GPAT and AGPAT.
- To discuss the physiological and pathophysiological roles of GPAT/AGPAT in glycerolipid metabolism.
Main Methods:
- Literature review of recent studies.
- Analysis of gene identification and genetically manipulated animal models.
- Discussion of enzymatic mechanisms and metabolic pathways.
Main Results:
- GPAT/AGPAT enzymes are central to de novo synthesis of triacylglycerol (TAG) and glycerophospholipids.
- Roles in TAG synthesis and obesity-related diseases have been elucidated.
- Specific isoforms are implicated in phospholipid fatty acid remodeling.
Conclusions:
- GPAT/AGPAT family enzymes play significant roles in lipid metabolism.
- Understanding these enzymes is critical for addressing metabolic disorders like obesity.
- Further research into GPAT/AGPAT functions will advance lipid science.
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