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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Deep brain stimulation: new directions.

T Ostergard¹, J P Miller

¹Department of Neurological Surgery University Hospitals Case Medical Center Cleveland, OH, USA - jonathan.miller@UHHospitals.org.

Journal of Neurosurgical Sciences

|November 25, 2014

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) is expanding beyond movement disorders to treat psychiatric and neurological conditions. Its reversible and programmable nature allows for safe exploration of new therapeutic targets.

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Area of Science:

Neuromodulation
Neurosurgery
Neuroscience

Background:

Deep brain stimulation (DBS) is established for movement disorders.
Neurosurgical lesioning historically informed DBS for psychiatric conditions like OCD.
Recent advancements expand DBS applications to diverse neurological and psychiatric conditions.

Purpose of the Study:

To highlight the expanding applications of DBS beyond traditional indications.
To discuss the paradigm shift in DBS target identification and application.
To emphasize the advantages of DBS for exploring new therapeutic targets.

Main Methods:

Leveraging innovative neural interface technology and novel target identification.
Building upon clinical effects observed in previous lesioning procedures.
Utilizing the reversible and programmable nature of DBS for research and treatment.

Main Results:

DBS is now indicated for major depressive disorder, Tourette's syndrome, addiction, and eating disorders.
Incidental discoveries are leading to treatments for cognitive disorders, headache syndromes, disorders of consciousness, and epilepsy.
DBS allows for controlled, on/off stimulation for blinded scientific evaluation.

Conclusions:

The reversible and programmable features of DBS facilitate safe investigation of new targets.
Advances in neuromodulation, neuroimaging, and neuroanatomy create new therapeutic possibilities.
Understanding emerging DBS therapies is crucial for treating complex neurological and psychiatric conditions.