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Updated: Apr 20, 2026
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
Osteonecrosis of the jaw in patient with denosumab therapy
Sergio Olate1, Francisca Uribe2, Felipe Martinez3
1Division of Oral and Maxillofacial Surgery & CIMA Group, Universidad de La Frontera Chile ; Center for Biomedical Research, Universidad Autónoma de Chile Chile.
Abstract:
Osteonecrosis (ON) of the jaw has previously been linked to the use of biphosphonates; however, new drugs, also shown similar conditions. This article presents a female patient with mandibular ON related to the use of denosumab. The 55-year-old presented with bone exposure with 8 months of evolution after a dental extraction. The patient began subcutaneous injections of 60 mg denosumab four months prior to the extraction and the lesion remained after the procedure. The patient, with 14 months of follow-up, show mandible ON with no favorable evolution. The clinical condition is presented and the literature of ON associated with denosumab is discussed.
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