[Use of erythrocytes for the intravital evaluation of adrenoreceptor function]

Administration of guanethidine (50 mg/kg) decreased the noradrenaline content in adrenergic neurons which led to an augmentation of the effector organ's adrenoreactivity in rats. The affinity of the erythrocytes' beta-adrenoreceptors to propranolol was enhanced and the parameters of their binding the fluorescent probe were changed. The data obtained suggest the possibility of using the erythrocytes for in vivo estimation of functional state of adrenoreactive system in animals and humans.