Community resources and technologies developed through the NIH Roadmap Epigenomics Program

Area of Science:

• Epigenomics and disease research

Background:

• The National Institutes of Health (NIH) Roadmap Epigenomics Program has generated significant resources.
• These resources are crucial for understanding epigenetics in various human diseases, including cancer.

Purpose of the Study:

• To highlight the utility of NIH Roadmap Epigenomics Program resources for researchers.
• To discuss advancements in epigenetics, including new technologies and disease associations.

Main Methods:

• Development of novel technologies for epigenetic assays and imaging.
• Generation of reference epigenome maps across diverse human cell types and tissues.
• Identification of new epigenetic modifications and their roles in disease.

Main Results:

• Creation of comprehensive reference epigenome maps for human cells and tissues.
• Advancement in epigenetic assay and imaging technologies.
• Enhanced understanding of epigenetic processes in human diseases.

Conclusions:

• The NIH Roadmap Epigenomics Program offers valuable tools for epigenomics research.
• Future research should address individual epigenomic variation, single-cell epigenomics, and environmental impacts.
• Improved technologies for epigenome manipulation are needed.