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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Inheritance of Chromatin Structures03:17

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

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DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Chromatin Modification in iPS Cells01:32

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Specific type epigenetic changes in cervical cancers.

Shuping Zhao1

  • 1Department of Gynecology, Qindao University School of Medicine, #16 Jiangsu Road, Shinan Qu, Qingdao, People's Republic of China, shuping.zhao@yahoo.com.

Methods in Molecular Biology (Clifton, N.J.)
|November 26, 2014
PubMed
Summary
This summary is machine-generated.

Cancer involves genetic and epigenetic changes, particularly in cervical cancer. Understanding these alterations is key to explaining tumor development and aggression during carcinogenesis.

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Area of Science:

  • Oncology
  • Genetics
  • Epigenetics

Background:

  • Cervical cancer arises from accumulated genetic and epigenetic alterations.
  • These changes impact regulatory genes, activating oncogenes and inactivating tumor suppressors.
  • The precise role of these changes in tumor aggression remains unclear.

Purpose of the Study:

  • To investigate the genetic and epigenetic changes in cervical cancer.
  • To understand how these alterations contribute to tumorigenesis and tumor aggression.

Main Methods:

  • Analysis of genetic alterations in cervical cancer.
  • Epigenetic profiling of cervical cancer tissues.
  • Correlation of molecular changes with disease stage and aggression.

Main Results:

  • Identified multiple genetic and epigenetic changes in cervical cancer.
  • Demonstrated that epigenetic alterations influence both viral and host gene expression.
  • These changes are linked to the multistep process of cervical carcinogenesis.

Conclusions:

  • Cervical cancer is characterized by a complex interplay of genetic and epigenetic modifications.
  • Epigenetic alterations play a significant role in the progression of cervical cancer.
  • Further research is needed to fully elucidate the mechanisms driving tumor aggression.