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Duodenal perforation: an unusual complication of sickle cell anemia

Can Acıpayam1, Güliz Aldıç2, Bülent Akçora3

  • 1Mustafa Kemal University, School of Medicine, Department of Pediatric Hematology and Oncology, Hatay, Turkey.

The Pan African Medical Journal
|November 26, 2014
PubMed

Insights

Childhood duodenal perforation is rare and life-threatening without surgery. This case highlights a unique instance of duodenal perforation in a patient with sickle cell anemia, a previously unreported association.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Hematology

Background:

  • Duodenal perforation in children is uncommon, with high mortality if not surgically managed.
  • Primary perforations often link to peptic ulcers and Helicobacter pylori; secondary perforations can indicate underlying conditions like Crohn disease, cystic fibrosis, or sickle cell anemia.

Observation:

  • A 14-year-old boy presented with acute abdominal and back pain, leading to a diagnosis of duodenal perforation post-surgery.
  • Helicobacter pylori was negative, and no risk factors were identified except for sickle cell anemia.

Findings:

  • Surgical intervention for the duodenal perforation was successful with no major complications.
  • This case represents the first documented instance of duodenal perforation in a patient with sickle cell anemia.

Implications:

  • Duodenal perforation is a rare but significant complication that can occur in patients with sickle cell anemia.
  • This finding expands the known spectrum of gastrointestinal complications associated with sickle cell anemia.

Keywords:
Sickle cell anemiaabdominal painduodenal perforation

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