Live-cell mass profiling: an emerging approach in quantitative biophysics
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Updated: Apr 20, 2026
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Thomas A Zangle1, Michael A Teitell2
1Department of Bioengineering, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Abstract:
Cell mass, volume and growth rate are tightly controlled biophysical parameters in cellular development and homeostasis, and pathological cell growth defines cancer in metazoans. The first measurements of cell mass were made in the 1950s, but only recently have advances in computer science and microfabrication spurred the rapid development of precision mass-quantifying approaches. Here we discuss available techniques for quantifying the mass of single live cells with an emphasis on relative features, capabilities and drawbacks for different applications.
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