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Related Experiment Video

Updated: Apr 20, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Spectrophotometric estimation of risperidone in tablets.

B K Jayanna¹, T D Devaraj¹, K P Roopa¹

¹Department of Chemistry, B. N. M. Institute of Technology, Bengaluru-560 070, India.

Indian Journal of Pharmaceutical Sciences

|November 27, 2014

Summary

A new spectrophotometric method accurately determines risperidone in tablets. This simple, rapid, and sensitive assay uses potassium permanganate oxidation for reliable pharmaceutical analysis.

Keywords:

1,10-phenanthroline Fe (II)Risperidone oxidation potassium permanganate spectrophotometry tablets

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Area of Science:

Analytical Chemistry
Pharmaceutical Analysis

Background:

Accurate determination of active pharmaceutical ingredients (APIs) is crucial for drug quality control.
Spectrophotometric methods offer a sensitive and cost-effective approach for API quantification.

Purpose of the Study:

To develop a simple, rapid, and highly sensitive spectrophotometric method for risperidone determination.
To validate the method for its suitability in pharmaceutical tablet formulations.

Main Methods:

The method involves the oxidation of risperidone using potassium permanganate in an alkaline medium.
The decrease in absorbance of 1,10-phenanthroline iron(II) complex was measured spectrophotometrically at 415 nm.

Main Results:

The method demonstrated linearity and obeyed Beer's Law in the concentration range of 5.0 to 40.0 μg/ml.
A high molar absorptivity of 7.3932 × 10(4) l/mol/cm was achieved.
The method proved to be sensitive and suitable for pharmaceutical formulations.

Conclusions:

The proposed spectrophotometric method is effective for the quantitative determination of risperidone in tablet dosage forms.
The simplicity, rapidity, and sensitivity make it a valuable tool for routine pharmaceutical analysis.