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Motion analysis and removal in intensity variation based OCT angiography.

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  • 1Department of Electrical and Computer Engineering, New Jersey Institute of Technology, 323 Dr Martin Luther King Jr Blvd, Newark, NJ USA.

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Bulk motion degrades optical coherence tomography (OCT) angiography quality. Adaptive thresholding effectively reduces motion artifacts in interframe signal variation based OCT angiography (isvOCA) for clearer microvasculature imaging.

Keywords:
(100.2000) Digital image processing(110.4500) Optical coherence tomography(170.2655) Functional monitoring and imaging

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Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology
  • Ophthalmic Imaging

Background:

  • Optical coherence tomography (OCT) angiography is crucial for visualizing microvasculature.
  • Image quality in OCT angiography can be compromised by bulk motion artifacts.
  • Interframe signal variation based OCT angiography (isvOCA) is susceptible to motion-induced background noise.

Purpose of the Study:

  • To investigate the impact of bulk motion on isvOCA image quality.
  • To develop and validate a method for reducing motion artifacts in isvOCA.
  • To demonstrate real-time, artifact-reduced OCT angiography for in vivo imaging.

Main Methods:

  • Theoretical and experimental analysis of bulk motion effects on isvOCA signals.
  • Development of an adaptive thresholding algorithm for motion artifact reduction.
  • Implementation of a 1.3μm spectral domain OCT system with GPU-accelerated processing.
  • In vivo microvasculature imaging of human skin.

Main Results:

  • Bulk motion was shown to increase the background noise in isvOCA images.
  • The proposed adaptive thresholding method significantly reduced motion artifacts.
  • Real-time, artifact-reduced OCT angiography was achieved.
  • High-quality in vivo imaging of human skin microvasculature was demonstrated.

Conclusions:

  • Bulk motion is a significant factor affecting isvOCA quality.
  • Adaptive thresholding is an effective strategy for mitigating motion artifacts in isvOCA.
  • This technique enhances the reliability of OCT angiography for clinical applications.