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Published on: February 24, 2023
CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel
Takashi Tokuda1, Masayuki Takahashi2, Kazuhiro Uejima1
1Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
Abstract:
A CMOS image sensor-based implantable glucose sensor based on an optical-sensing scheme is proposed and experimentally verified. A glucose-responsive fluorescent hydrogel is used as the mediator in the measurement scheme. The wired implantable glucose sensor was realized by integrating a CMOS image sensor, hydrogel, UV light emitting diodes, and an optical filter on a flexible polyimide substrate. Feasibility of the glucose sensor was verified by both in vitro and in vivo experiments.
