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Updated: Apr 20, 2026

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy
Published on: August 22, 2018
Rapid calculation of diffuse reflectance from a multilayered model by combination of the white Monte Carlo and
Kenichiro Yoshida1, Izumi Nishidate1
1Tokyo University of Agriculture & Technology, Graduate School of Bio-applications & Systems Engineering, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Abstract:
To rapidly derive a result for diffuse reflectance from a multilayered model that is equivalent to that of a Monte-Carlo simulation (MCS), we propose a combination of a layered white MCS and the adding-doubling method. For slabs with various scattering coefficients assuming a certain anisotropy factor and without absorption, we calculate the transition matrices for light flow with respect to the incident and exit angles. From this series of precalculated transition matrices, we can calculate the transition matrices for the multilayered model with the specific anisotropy factor. The relative errors of the results of this method compared to a conventional MCS were less than 1%. We successfully used this method to estimate the chromophore concentration from the reflectance spectrum of a numerical model of skin and in vivo human skin tissue.
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