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Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
Published on: December 29, 2023
The correlation between plasma tissue factor and interleukin 18 and their significance in patients with acute
Qiaowen Li1, Yulan Kuang, Jian Qiu
1Department of Cardiology, The Medical College of Jinan University, Qingyuan City People's Hospital, Guangzhou, Guangdong, China.
Insights
In patients with acute coronary syndrome (ACS), higher levels of plasma tissue factor (TF) and interleukin 18 (IL-18) were observed. These markers showed a strong correlation, suggesting a link between inflammation and coagulation in ACS.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Hematology
Background:
- Inflammation and coagulation systems may interact and influence disease processes.
- Understanding this interaction is crucial for managing cardiovascular diseases.
Purpose of the Study:
- To investigate the relationship between plasma tissue factor (TF) and interleukin 18 (IL-18) in patients with coronary heart disease (CHD).
- To determine if this relationship is present in acute coronary syndrome (ACS) and how it changes with treatment.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma TF and IL-18 levels.
- 118 CHD patients were categorized into ACS and stable angina pectoris groups.
- Levels were assessed at admission and after 7 days and 1 month of treatment.
Main Results:
- Patients with ACS had significantly higher plasma TF and IL-18 levels than stable angina patients (P < 0.01).
- A strong positive correlation between TF and IL-18 was found in ACS patients upon admission (r = 0.74, P < 0.01).
- This correlation decreased significantly after treatment, becoming non-significant after 1 month.
Conclusions:
- Plasma TF and IL-18 levels are elevated in ACS patients, indicating a link between inflammation and coagulation.
- These markers play a significant role in the occurrence and progression of ACS.
- The interaction between inflammation and coagulation is dynamic and influenced by treatment.
Abstract:
Studies suggested that the activation of the coagulation system and inflammation mutually may reinforce each other in some cases. In this study, we test the plasma tissue factor (TF) and interleukin 18 in patients with coronary heart disease (CHD) before and after treatment and aim to determine whether this relationship exists in patients with CHD. The levels of plasma TF and IL-18 from 118 patients with CHD were determined by enzyme-linked immunosorbent assay. One hundred and eighteen patients were divided into acute coronary syndrome (ACS) group (61 cases) and stable angina pectoris group (51 cases). Upon admission, patients with ACS showed significantly higher levels of plasma TF and interleukin 18 compared with those having stable angina (P < 0.01), and the levels decreased after treatment; levels of plasma TF and interleukin 18 of patients with ACS were closely and positively correlated (r = 0.74, P < 0.01); after 7 days of treatment, the correlation decreased (r = 0.53, P > 0.05); and after 1 month of treatment, no significant correlation can be detected between the two (r = 0.18, P > 0.05). The results suggest that levels of plasma TF and interleukin 18 are significantly increased in patients with ACS, and there is significant correlation between the two, indicating an interaction between inflammation and coagulation in patients with ACS and an important role of these two in the occurrence and development of such disease.
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