Preparation and study of a naproxen ion-selective electrode

Area of Science:

• Analytical Chemistry
• Electrochemistry
• Materials Science

Background:

• Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID).
• Accurate and cost-effective methods for naproxen determination are crucial for therapeutic drug monitoring and quality control.
• Existing methods may be time-consuming or expensive.

Purpose of the Study:

• To develop and characterize a novel naproxen membrane electrode.
• To evaluate the electrode's performance, including sensitivity, detection limit, and selectivity.
• To assess the electrode's applicability for real-world sample analysis.

Main Methods:

• Fabrication of naproxen membrane electrodes using various plasticizers and tetraoctylammonium (NAP-TOA).
• Electrochemical characterization including sensitivity, linear range, and limit of detection determination.
• Selectivity assessment against common interfering substances and pharmaceutical excipients.
• Application in analyzing naproxen in urine and pharmaceutical formulations using calibration curve and standard addition methods.

Main Results:

• The developed naproxen electrode exhibited a sensitivity of -59.2 mV decade(-1) within a linear range of 10(-4)-10(-1) mol L(-1).
• A low limit of detection (1.80×10(-5) mol L(-1)) and a rapid response time (15-20s) were achieved.
• The electrode demonstrated good selectivity and stability, with a lifetime of approximately 20 months.
• Successful determination of naproxen in urine and pharmaceutical samples with results comparable or superior to pharmacopoeial methods.

Conclusions:

• The naproxen membrane electrode is a cost-effective, reliable, and sensitive analytical tool.
• Its ease of use, long lifetime, and applicability to real samples make it a valuable alternative for naproxen quantification.
• This electrode holds promise for routine analysis in clinical and pharmaceutical settings.