Polymeric Membrane Electrodes for a Fast End Cost-Effective Potentiometric Determination of Octenidine...

Determining the active substance content in the tested product is an essential part of research for overall assessment of the quality of a medicinal substance. This role can be successfully performed by membrane electrodes that are selective for a specific drug. The novelty of the presented research is the development of the first ion-selective electrode with a polymer membrane phase with the octenidine (OCT) function. Classical ion-selective electrodes (ISE), polymer electrodes with an internal Ag/AgCl electrode, and electrode bodies with glassy carbon were used for the research. The membranes were prepared based on cation exchangers from the borate group and neutral cyclodextrin. All sensors have good parameters, e.g., the polymer electrode with KtpClPB is characterised by a wide linear range of -logc 6-3, a low limit of detection 5 × 10^-7 M, and a near-Nernstian, reproducible slope of characteristics of 31.41 ± 1.14 mV/decade. It can be seen that a stable, reversible potential and a short response time were achieved for this sensor. The obtained favourable selectivity coefficients of the electrode determined in relation to excipients allowed direct determination of octenidine, e.g., in lozenges. The results obtained with the calibration curve method show a recovery of 97% and a precision of SD 2.3 mg/L, which indicates that the data are consistent with the pharmacopoeia requirements.