Clinical study on Kangquan Recipe (康泉方) for benign prostatic hyperplasia patients: a randomized controlled trial

Area of Science:

• Urology
• Integrative Medicine
• Pharmacology

Background:

• Benign prostatic hyperplasia (BPH) is a common condition in aging men, causing lower urinary tract symptoms.
• Current treatments for BPH have limitations and potential side effects.
• Herbal remedies are increasingly explored for BPH management.

Purpose of the Study:

• To evaluate the efficacy and safety of Kangquan Recipe (KQR) in patients diagnosed with BPH.
• To compare KQR's effects against a known BPH treatment, cernilton.

Main Methods:

• A randomized controlled trial involving 106 BPH patients.
• Participants were assigned to receive either KQR or cernilton orally for 24 weeks.
• Outcomes measured included International Prostatic Symptom Score (I-PSS), quality of life (QOL), urinary flow rates (Qmax, Qave), residual urine volume (RUV), and total prostatic volume (TPV).

Main Results:

• KQR significantly reduced I-PSS scores compared to the control group.
• Patients treated with KQR showed significant improvements in Qmax and Qave.
• KQR led to a significant decrease in RUV and TPV.
• Adverse reaction rates were comparable between the KQR and control groups.

Conclusions:

• Kangquan Recipe (KQR) demonstrates significant effectiveness in improving urinary symptoms and flow parameters in BPH patients.
• KQR is a safe therapeutic option for managing benign prostatic hyperplasia.