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The UCSC Genome Browser database: 2015 update.
Kate R Rosenbloom1, Joel Armstrong2, Galt P Barber2
1Center for Biomolecular Science and Engineering, CBSE, UC Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA kate@soe.ucsc.edu.
Nucleic Acids Research
|November 28, 2014
Summary
The UCSC Genome Browser offers updated human genome assemblies and comparative genomics tools for researchers. It now features new species browsers, enhanced visualizations, and improved data sharing via hubs.
Area of Science:
- Genomics
- Bioinformatics
- Comparative Genomics
Background:
- The UCSC Genome Browser, established in 2001, serves as a vital resource for genome assemblies and annotations.
- It supports scientists and students globally with comprehensive genomic data.
Purpose of the Study:
- To detail recent advancements and expansions of the UCSC Genome Browser database and its associated tools.
- To highlight new features, species data, and distribution mechanisms enhancing genomic research accessibility.
Main Methods:
- Released the GRCh38 human genome reference assembly (UCSC hg38) with a new browser.
- Developed a 100-species multiple alignment and conservation track for comparative genomics.
- Introduced Genome Browser in a Box (GBiB) for novel distribution.
- Created browsers for new species and expanded visualization options.
- Increased public data hubs by threefold, supporting data sharing.
Main Results:
- The UCSC Genome Browser now includes the GRCh38 human genome assembly and extensive comparative genomics data.
- New browsers for Chinese hamster, elephant shark, and minke whale have been added.
- Enhanced display features like stacked color graphs and region highlighting improve data interpretation.
- The adoption of UCSC track and assembly hubs has significantly increased for data sharing.
Conclusions:
- The UCSC Genome Browser continues to evolve as a leading resource for genomic information.
- Recent updates enhance comparative genomics, data accessibility, and user-driven data sharing.
- These advancements empower the scientific community with more comprehensive and user-friendly genomic tools.
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