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Could elevated platelet-lymphocyte ratio predict left ventricular systolic dysfunction in patients with non-ST

Adem Bekler1, Emine Gazi, Mustafa Yılmaz

  • 1Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University; Çanakkale-Turkey. adembekler27@gmail.com.

Anatolian Journal of Cardiology
|November 29, 2014
PubMed

Insights

A high platelet-lymphocyte ratio (PLR) independently predicts left ventricular systolic dysfunction (LVSD) in patients with non-ST elevated acute coronary syndrome (NST-ACS). This finding offers a simple biomarker for assessing cardiac risk in these patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Acute Coronary Syndromes

Background:

  • The platelet-lymphocyte ratio (PLR) has shown prognostic value in non-ST elevated myocardial infarction (NSTEMI) and various cancers.
  • Left ventricular systolic dysfunction (LVSD) is a critical complication following acute coronary syndromes.
  • Predictive markers for LVSD in non-ST elevated acute coronary syndrome (NST-ACS) are essential for risk stratification.

Purpose of the Study:

  • To investigate the predictive value of the platelet-lymphocyte ratio (PLR) for left ventricular systolic dysfunction (LVSD).
  • To assess the association between a high PLR and the presence of LVSD in patients diagnosed with NST-ACS.

Main Methods:

  • A cohort of 220 patients with NST-ACS was analyzed.
  • Patients were stratified into tertiles based on admission PLR values, with high PLR defined as >135.6.
  • LVSD was defined as an ejection fraction ≤ 40%, and logistic regression analysis was employed.

Main Results:

  • The high PLR group exhibited older age, higher rates of previous myocardial infarction and NSTEMI, and more narrowed coronary arteries.
  • Patients with high PLR had significantly lower left ventricular ejection fraction, higher platelet counts, and lower lymphocyte and triglyceride levels.
  • A PLR >135.6 was identified as an independent predictor of systolic dysfunction in multivariate analyses (β: 0.306, p=0.001).

Conclusions:

  • Elevated platelet-lymphocyte ratio (PLR) is a significant and independent predictor of left ventricular systolic dysfunction (LVSD).
  • High PLR serves as a valuable prognostic biomarker for identifying patients with NST-ACS at risk of developing LVSD.
Abstract

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