Related Experiment Video
Updated: Apr 20, 2026

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Published on: June 14, 2018
Ultrasensitive SERS assay of lysozyme using a novel and unique four-way helical junction molecule probe for signal
Zhen Zhang1, Yuanyuan Wang, Fuwei Zheng
1Shandong Province Key Laboratory of Detection Technology for Tumor Makers, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China. shushzhang@126.com.
Abstract:
A unique four-way helical junction molecule (FHJM) probe was ingeniously designed, and firstly introduced into DNA signal amplification as a novel Surface-enhanced Raman scattering (SERS) probe. Significantly, a new FHJM-SERS method was successfully developed for lysozyme detection with high sensitivity and specificity.
Related Concept Videos
Enzyme-Linked Immunosorbent Assay
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen. Enzyme-substrate reaction allows the antigen to be visualized or...
Labeling DNA Probes
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

