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Updated: Apr 20, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
Published on: June 23, 2014
Novel roles of perivascular nerves on neovascularization
Lei Hao1, Zhongmin Zou, Hong Tian
1Department of Neurology, No. 324 Hospital of PLA, Chongqing, 400020, China, haolei1102@163.com.
Abstract:
Neovascularization, including angiogenesis, arteriogenesis and vasculogenesis, occurs in physiological and pathological state. Efficient and controlled reconstruction of functional vascular network is necessary. Nerves and blood vessels establish intricate branching network in every organ which share anatomical and functional characteristics. Nerves direct vessel branching patterns and arterial differentiation in the developmental embryonic limb skin. Various neurotransmitters exert antiapoptotic, chemotactic and proliferative effect on EC and SMC, and modulate all the phases of neovascularization. Hence, we proposed that the perivascular nerves may play critical roles in neovascularization.
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