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Updated: Jul 21, 2026
08:02
Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
[How should the plasma ACTH level in treated Addison's disease patients be interpreted?].
M Pehuet-Figoni1, X Bertagna, F Girard
1Centre de Recherches des Maladies Endocriniennes et Métaboliques, Hôpital Cochin, Paris.
Annales D'Endocrinologie
|January 1, 1989
Summary
Addisonian patients
Area of Science:
- Endocrinology
- Hormone Replacement Therapy
Context:
- Addison's disease management
- Adrenocorticotropic hormone (ACTH) assessment
Purpose:
- Establish ACTH plasma level ranges for optimal Addison's disease treatment.
- Differentiate between over-, well-, and under-treated Addisonian patients.
Summary:
- Analyzed ACTH plasma levels in 73 Addisonian patients and 40 controls.
- Defined new criteria for treatment adequacy based on ACTH levels (low <75 pg/ml, optimal 75-700 pg/ml, high >700 pg/ml).
- Observed high plasma renin activity in under-treated patients, suggesting renin-angiotensin system involvement.
Impact:
- Provides a novel, quantifiable method for assessing glucocorticoid replacement therapy in Addison's disease.
- Highlights potential mechanisms contributing to elevated ACTH in inadequately treated patients.
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