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Updated: Apr 20, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Cognitive function in hypertensive children
Marc B Lande1, Juan C Kupferman
1Division of Pediatric Nephrology, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Ave., Box 777, Rochester, NY, 14642, USA, marc_lande@urmc.rochester.edu.
Insights
Children with hypertension may show cognitive differences compared to healthy peers. Ongoing research is exploring these neurocognitive differences in a large, multicenter study.
Area of Science:
- Pediatric Hypertension Research
- Neurocognitive Function in Children
Background:
- Hypertension in young adults is linked to reduced neurocognitive performance.
- Preliminary evidence suggests cognitive differences in children with hypertension.
Purpose of the Study:
- To investigate neurocognitive performance in children with primary hypertension.
- To compare cognitive function between hypertensive and normotensive children.
Main Methods:
- Utilizing data from a current, multicenter, ongoing study.
- Informing study design from adult hypertension cognition literature and prior pediatric studies.
Main Results:
- Preliminary studies indicate potential differences in neurocognitive test performance.
- Cerebrovascular reactivity differences are also observed between groups.
Conclusions:
- Further research is needed to understand cognitive impacts of childhood hypertension.
- A robust, multicenter approach is crucial for studying pediatric hypertension and cognition.
Abstract:
Young hypertensive adults demonstrate decreased performance on neurocognitive testing compared with that of normotensive controls. There is emerging, preliminary evidence that children with hypertension also manifest cognitive differences when compared to normotensive controls. These preliminary studies consist mostly of database and single-center studies that focus primarily on differences in neurocognitive test performance and differences in cerebrovascular reactivity between hypertensive and normotensive subjects. Lessons from the literature on cognition in adult hypertensives and experience from the preliminary studies in children informed the design of a current, multicenter, ongoing study of cognition in children with primary hypertension.
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