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Updated: Apr 20, 2026
Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model
Published on: September 20, 2020
Enhanced infarct myocardium repair mediated by thermosensitive copolymer hydrogel-based stem cell transplantation
1Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China Shanghai Institute of Cardiovascular Disease, Shanghai 200032, P. R. China Department of Cardio-Thoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, P. R. China.
Abstract:
Mesenchymal stem cell (MSC) transplantation by intramyocardial injection has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, low retention and survival of grafted MSCs hinder its further application. In this study, copolymer with N-isopropylacrylamide/acrylic acid/2-hydroxylethyl methacrylate-poly(ɛ-caprolactone) ratio of 88:9.6:2.4 was bioconjugated with type I collagen to construct a novel injectable thermosensitive hydrogel. The injectable and biocompatible hydrogel-mediated MSC transplantation could enhance the grafted cell survival in the myocardium, which contributed to the increased neovascularization, decreased interstitial fibrosis, and ultimately improved heart function to a significantly greater degree than regular MSC transplantation. We suggest that this novel hydrogel has the potential for future stem cell transplantation.
