Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

2.8K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.8K
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

10.6K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
10.6K
Pulse rhythm01:30

Pulse rhythm

1.7K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.7K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

812
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
812

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seen but not heard: A qualitative interview study exploring the views and experiences of children and young people referred to Child and Adolescent Mental Health Services for support with suicidality.

PLOS mental health·2026
Same author

Embedding Patient and Public Engagement in a Cancer Project: Protocol for a Qualitative Study.

JMIR research protocols·2026
Same author

Role of autonomic receptors in ethyl ferulate-induced cardiovascular effects in normotensive and hypertensive female rats.

Pflugers Archiv : European journal of physiology·2026
Same author

Synchronization-Dissipation in the Cardiorespiratory System.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Targeting hypertension through natural phenolics: The multifaceted role of cinnamic acid and its derivatives.

Pflugers Archiv : European journal of physiology·2026
Same author

Correcting model error bias in estimations of neuronal dynamics from time series observations.

Scientific reports·2026

Related Experiment Video

Updated: Apr 20, 2026

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
08:52

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

Published on: February 17, 2015

10.2K

Silicon central pattern generators for cardiac diseases.

Alain Nogaret1, Erin L O'Callaghan, Renata M Lataro

  • 1Department of Physics, University of Bath, Bath, BA2 7AY, UK.

The Journal of Physiology
|November 30, 2014
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel silicon hardware central pattern generator (hCPG) to restore respiratory sinus arrhythmia (RSA) in rats. This bioelectronic medicine approach enables adaptive cardiac pacing, offering potential for heart disease therapies.

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.4K
Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
08:33

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

1.1K

Related Experiment Videos

Last Updated: Apr 20, 2026

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
08:52

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

Published on: February 17, 2015

10.2K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.4K
Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
08:33

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

1.1K

Area of Science:

  • Bioelectronic Medicine
  • Computational Neuroscience
  • Biophysics

Background:

  • Cardiac rhythm management devices currently do not treat heart failure.
  • Millions worldwide are affected by heart failure.
  • Existing technologies lack beat-to-beat adaptation for cardiac pacing.

Purpose of the Study:

  • To introduce a novel technological platform for heart disease using silicon hardware central pattern generators (hCPGs).
  • To emulate biological central pattern generators (bCPGs) for adaptive cardiac pacing.
  • To investigate the restoration of respiratory sinus arrhythmia (RSA) using hCPGs.

Main Methods:

  • Developed a scalable hCPG with Hodgkin-Huxley type neurons and synapses.
  • Modeled cardio-respiratory oscillators in the medulla oblongata.
  • Used diaphragmatic electromyography input to stimulate the vagus nerve in rats to restore RSA.

Main Results:

  • Successfully restored RSA in rats using the hCPG system.
  • Demonstrated adaptive stimulation based on respiratory rate.
  • Validated tuneable control over RSA depth and timing relative to respiratory phase.

Conclusions:

  • The novel hCPG system shows promise for bioelectronic medicine and adaptive cardiac pacing.
  • This technology enables beat-to-beat adaptation in response to physiological feedback.
  • Pioneering studies pave the way for analyzing RSA's role in cardiac disease and its therapeutic potential.